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NGN: Neuro-Gastroentérologie & Nutrition
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Les articles scientifiques

2023

  • Traditional fermented milk products of Eastern Mediterranean countries: A cultural heritage to preserve.Reine AbiKhalil*, Sophie Yvon*, Christel Couderc, Gwenaelle Jard, Rabih El Rammouz, Pierre Abi Nakhoul, Hélène Eutamène, Marie-José Ayoub, Hélène Tormo. August 2023 International Dairy Journal DOI :10.1016/j.idairyj.2023.105768
  • Microbial Dynamics during labneh Ambaris Production in Earthenware Jars. Abi Khalil R, Couderc C, Yvon S, Sicard D, Bigey F, Jard G, El Rammouz R, Abi Nakhoul P, Eutamène H, Ayoub MJ, Tormo H. 2023 Aug 21;12(16):3131. doi: 10.3390/foods12163131. PMID: 37628130; PMCID: PMC10453334.
  • Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet-Santé Cohort and an In Vivo Intervention Study in Rats. Mervant L, Tremblay-Franco M, Olier M, Jamin E, Martin JF, Trouilh L, Buisson C, Naud N, Maslo C, Héliès-Toussaint C, Fouché E, Kesse-Guyot E, Hercberg S, Galan P, Deschasaux-Tanguy M, Touvier M, Pierre F, Debrauwer L, Guéraud F. Mol Nutr Food Res. 2023 Mar;67(5):e2200432. doi: 10.1002/mnfr.202200432. Epub 2023 Feb 2. PMID: 36647294.
  • Microbial communities and main features of labneh Ambaris, a traditional Lebanese fermented goat milk product. Abi Khalil R, Yvon S, Couderc C, Belahcen L, Jard G, Sicard D, Bigey F, El Rammouz R, Abi Nakhoul P, Eutamène H, Tormo H, Ayoub MJ. J Dairy Sci. 2023 Feb;106(2):868-883. doi: 10.3168/jds.2022-22275. Epub 2022 Dec 19. PMID: 36543637.
  • Fate, uptake and gut toxicity of two colloidal silver products in mice: how micro X-ray fluorescence, micro X-ray absorption spectroscopy and near-infrared spectroscopy provide new insights in food nanotoxicology. Gillois, K., Rivard, C., Levasseur-Garcia, C., Bezirard, V., Terrisse, H., Leonard, R., ... & Robert, H. (2023).  Environmental Science: Nano, 10(3), 902-921.
  • Microplastics: What happens in the human digestive tract? First evidences in adults using in vitro gut models. Fournier E, Leveque M, Ruiz P, Ratel J, Durif C, Chalancon S, Amiard F, Edely M, Bezirard V, Gaultier E, Lamas B, Houdeau E, Lagarde F, Engel E, Etienne-Mesmin L, Blanquet-Diot S, Mercier-Bonin M. J Hazard Mater. 2023 Jan 15;442:130010. doi: 10.1016/j.jhazmat.2022.130010. Epub 2022 Sep 21. PMID: 36182891.
  • Profiling of PFOA-Exposed Mouse Liver by Multi-Modal Mass Spectrometry Analysis. Stoffels CBA, Angerer TB, Robert H, Poupin N, Lakhal L, Frache G, Mercier-Bonin M, Audinot JN. Lipidomic Anal Chem. 2023 Apr 7. doi: 10.1021/acs.analchem.2c05470. Epub ahead of print. PMID: 37027489
  • O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases. Labourel A, Parrou JL, Deraison C, Mercier-Bonin M, Lajus S, Potocki-Veronese G.  Essays Biochem. 2023 Apr 18;67(3):331-344. doi: 10.1042/EBC20220153. PMID: 36912232.

2022

  • Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring. Mazenc A, Mervant L, Maslo C, Lencina C, Bézirard V, Levêque M, Ahn I, Alquier-Bacquié V, Naud N, Héliès-Toussaint C, Debrauwer L, Chevolleau S, Guéraud F, Pierre FHF, Théodorou V, Olier M. Redox Biol. 2022 Jul;53:102333. doi: 10.1016/j.redox.2022.102333. Epub 2022 May 12. PMID: 35588638; PMCID: PMC9119830
  • Human milk oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis. Ferrier L, Eutamène H, Siegwald L, Marquard AM, Tondereau V, Chevalier J, Jacot GE, Favre L, Theodorou V, Vicario M, Rytz A, Bergonzelli G, Garcia-Rodenas CL. J Nutr Biochem. 2022 Jan;99:108865. doi: 10.1016/j.jnutbio.2021.108865. Epub 2021 Sep 25. PMID: 34582967.
  • In vitro models of gut digestion across childhood: current developments, challenges and future trends. Fournier E, Roussel C, Dominicis A, Ley D, Peyron MA, Collado V, Mercier-Bonin M, Lacroix C, Alric M, Van de Wiele T, Chassard C, Etienne-Mesmin L, Blanquet-Diot S. Biotechnol Adv. 2022 Jan-Feb;54:107796. doi: 10.1016/j.biotechadv.2021.107796. Epub 2021 Jul 9. PMID:34252564.
  • Exposure to polyethylene microplastics alters immature gut microbiome in an infant in vitro gut model. Fournier E, Ratel J, Denis S, Leveque M, Ruiz P, Mazal C, Amiard F, Edely M, Bezirard V, Gaultier E, Lamas B, Houdeau E, Engel E, Lagarde F, Etienne-Mesmin L, Mercier-Bonin M, Blanquet-Diot S. J Hazard Mater. 2023 Feb 5;443(Pt B):130383. doi: 10.1016/j.jhazmat.2022.130383. Epub 2022 Nov 11. PMID: 36444070.
  • A child is not an adult: development of a new in vitro model of the toddler colon. Fournier E, Denis S, Dominicis A, Van de Wiele T, Alric M, Mercier-Bonin M, Etienne-Mesmin L, Blanquet-Diot S. Appl Microbiol Biotechnol. 2022 Nov;106(21):7315-7336. doi: 10.1007/s00253-022-12199-0. Epub 2022 Oct 7. PMID: 36202936.
  • Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, Daveran-Mingot ML, Theodorou V, Eutamene H, Mercier-Bonin M, Cocaign-Bousquet M. Elife. 2022 Jun 21;11:e77100. doi: 10.7554/eLife.77100. PMID: 35727704; PMCID: PMC9213000.
  • Artisanal Household Milk Pasteurization Is Not a Determining Factor in Structuring the Microbial Communities of Labneh Ambaris: A Pilot Study. Abi Khalil R, Couderc C, Yvon S, Jard G, Sicard D, Bigey F, El Rammouz R, Abi Nakhoul P, Eutamène H, Tormo H, Ayoub MJ. Foods. 2022 Dec 1;11(23):3S874.doi: 10.3390/foods11233874. PMID: 36496682; PMCID: PMC9740543.

2021

  • Bisphenol A, S or F mother's dermal impregnation impairs offspring immune responses in a dose and sex-specific manner in mice. Malaisé Y, Lencina C, Cartier C, Olier M, Ménard S, Guzylack-Piriou L. Sci Rep. 2021 Jan 18;11(1):1650. doi: 10.1038/s41598-021-81231-6. PMID: 33462300; PMCID: PMC7813853.
  • Microplastics in the human digestive environment: A focus on the potential and challenges facing in vitro gut model development. Fournier E, Etienne-Mesmin L, Grootaert C, Jelsbak L, Syberg K, Blanquet-Diot S, Mercier-Bonin M. J Hazard Mater. 2021 Aug 5;415:125632. doi: 10.1016/j.jhazmat.2021.125632.  Epub 2021 Mar 11. PMID: 33770682.
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  • Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products. Gillois K, Stoffels C, Leveque M, Fourquaux I, Blesson J, Mils V, Cambier S, Vignard J, Terrisse H, Mirey G, Audinot JN, Theodorou V, Ropers MH, Robert H, Mercier-Bonin M.  Sci Total Environ. 2021 Feb 1;754:142324. doi: 10.1016/j.scitotenv.2020.142324. Epub 2020 Sep 17. PMID: 33254900.
  • In vitro digestion of food grade TiO2 (E171) and TiO2 nanoparticles: physicochemical characterization and impact on the activity of digestive enzymes. Dudefoi W, Rabesona H, Rivard C, Mercier-Bonin M, Humbert B, Terrisse H, Ropers MH. Food Funct. 2021 Jul 5;12(13):5975-5988. doi: 10.1039/d1fo00499a. PMID: 34032251.
  • Revisiting definition and assessment of intestinal trans-epithelial passage. Ilchmann-Diounou H, Buleon M, Bacquie V, Theodorou V, Denis C, Menard S. Cell Mol Life Sci. 2021 Dec;78(24):8157-8164. doi: 10.1007/s00018-021-04000-8. Epub 2021 Nov 3. PMID: 34731253; PMCID: PMC8629865.
  • The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice. Barretto SA, Lasserre F, Huillet M, Régnier M, Polizzi A, Lippi Y, Fougerat A, Person E, Bruel S, Bétoulières C, Naylies C, Lukowicz C, Smati S, Guzylack L, Olier M, Théodorou V, Mselli-Lakhal L, Zalko D, Wahli W, Loiseau N, Gamet- Payrastre L, Guillou H, Ellero-Simatos S. Microbiome. 2021 Apr 20;9(1):93. doi: 10.1186/s40168-021-01050-9. PMID: 33879258; PMCID: PMC8059225.

2020

  • Inczefi O, Bacquié V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero- Simatos S, Eutamène H, Bétoulières C, Thomas J, Lainé J, Gros L, Lévêque M, Leonard R, Harkat C, Robbe-Masselot C, Róka R, Mercier-Bonin M, Theodorou V, Darnaudéry M, Turner JR, Ferrier L. Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses. Cell Mol Gastroenterol Hepatol. 2020;10(1):206-208.e3. doi: 10.1016/j.jcmgh.2020.02.008. Epub 2020 Mar 6. PMID: 32147490; PMCID: PMC7296230.
  • Bi Y, Marcus AK, Robert H, Krajmalnik-Brown R, Rittmann BE, Westerhoff P, Ropers MH, Mercier-Bonin M. The complex puzzle of dietary silver nanoparticles, mucus and microbiota in the gut. J Toxicol Environ Health B Crit Rev. 2020;23(2):69-89. doi: 10.1080/10937404.2019.1710914. Epub 2020 Jan 10. PMID: 31920169.
  • Martín R, Bottacini F, Egan M, Chamignon C, Tondereau V, Moriez R, Knol J,Langella P, Eutamene H, Smokvina T, van Sinderen D. The Infant-Derived<i>Bifidobacterium bifidum</i> Strain CNCM I-4319 Strengthens Gut Functionality.Microorganisms. 2020 Aug 28;8(9):1313.doi:10.3390/microorganisms8091313. PMID:32872165; PMCID: PMC7565306.
  • Theodorou V,Beaufrand C, Yvon S, Laforge G, Burmeister Y, Müller A, Seilheimer B, Bueno L, Eutamene H. The multicomponent medication Spascupreel attenuates stress-induced gut dysfunction in rats. Neurogastroenterol Motil. 2020 May;32(5):e13798. doi: 10.1111/nmo.13798. Epub 2020 Feb 14. PMID: 32059072; PMCID: PMC7217055.
  • Beaumont M, Paës C, Mussard E, Knudsen C, Cauquil L, Aymard P, Barilly C, Gabinaud B, Zemb O, Fourre S, Gautier R, Lencina C, Eutamène H,Theodorou V, Canlet C, Combes S. Gut microbiota derived metabolites contribute to intestinal barrier maturation at the suckling-to-weaning transition. Gut Microbes. 2020 Sep 2;11(5):1268-1286. doi: 10.1080/19490976.2020.1747335. Epub 2020 Apr 30. PMID: 32352849; PMCID: PMC7524271.
  • Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology. 2020 Feb;158(3):652-663.e6. doi: 10.1053/j.gastro.2019.10.037. Epub 2019 Nov 9. PMID: 31711923.
  • Payros D, Ménard S, Laffitte J, Neves M, Tremblay-Franco M, Luo S, Fouche E, Snini SP, Theodorou V, Pinton P, Oswald IP. The food contaminant, deoxynivalenol, modulates the Thelper/Treg balance and increases inflammatory bowel diseases. Arch Toxicol. 2020 Sep;94(9):3173-3184. doi: 10.1007/s00204-020-02817-z. Epub 2020 Jul 2. PMID: 32617661.
  • Keller J, Chevolleau S, Noguer-Meireles MH, Pujos-Guillot E, Delosière M, Chantelauze C, Joly C, Blas-Y-Estrada F, Jouanin I, Durand D, Pierre F, Debrauwer L, Theodorou V, Guéraud F. Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation. Antioxidants (Basel). 2020 Dec 17;9(12):1293. doi: 10.3390/antiox9121293. PMID: 33348697; PMCID: PMC7766870.
  • Coméra C, Cartier C, Gaultier E, Catrice O, Panouille Q, El Hamdi S, Tirez K, Nelissen I, Théodorou V, Houdeau E. Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO<sub>2</sub> particles: an in vivo and ex vivo study in mice. Part Fibre Toxicol. 2020 Jun 11;17(1):26. doi: 10.1186/s12989-020-00357-z. PMID: 32527323; PMCID: PMC7345522.
  • Malaisé Y, Lencina C, Placide F, Bacquié V, Cartier C, Olier M, Buettner M, Wallbrecht M, Ménard S, Guzylack-Piriou L. Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice. Food Chem Toxicol. 2020 Dec;146:111773. doi: 10.1016/j.fct.2020.111773. Epub 2020 Oct 1. PMID: 33011352.
  • Malaisé Y, Lencina C, Cartier C, Olier M, Ménard S, Guzylack-Piriou L. Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice. Environ Health. 2020 Aug 31;19(1):93. doi: 10.1186/s12940-020-00614-w. PMID: 32867778;PMCID: PMC7457519.

2019

  • Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology. 2019 Nov 8. pii: S0016-5085(19)41528-X. doi: 10.1053/j.gastro.2019.10.037.
  • Ilchmann-Diounou H, Olier M, Lencina C, Riba A, Barretto S, Nankap M, Sommer C, Guillou H, Ellero-Simatos S, Guzylack-Piriou L, Théodorou V, Ménard S. Early life stress induces type 2 diabetes-like features in ageing mice. Brain Behav Immun. 2019 Aug;80:452-463. doi: 10.1016/j.bbi.2019.04.025.
  • Martin OCB, Olier M, Ellero-Simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V,  Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. Microbiome. 2019 May 6;7(1):72. doi:10.1186/s40168-019-0685-7.
  • Rincel M, Olier M, Minni A, de Oliveira CM, Matime Y, Gaultier E, Grit I, Helbling JC, Costa AM, Lépinay A, Moisan MP, Layé S, Ferrier L, Parnet P, Theodorou V, Darnaudéry M. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (Berl). 2019 May;236(5):1583-1596. doi: 10.1007/s00213-019-05252-w.
  • Yvon S, Schwebel L, Belahcen L, Tormo H, Peter M, Haimoud-Lekhal DA, Eutamene H, Jard G. Effects of thermized donkey milk with lysozyme activity on altered gut barrier in mice exposed to water-avoidance stress. J Dairy Sci. 2019 Sep;102(9):7697-7706. doi: 10.3168/jds.2019-16642.
  • Maes E, Sadovskaya I, Lévêque M, Elass-Rochard E, Payré B, Grard T, Théodorou V, Guérardel Y, Mercier-Bonin M. Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis. Glycoconj J. 2019 Feb;36(1):39-55. doi:10.1007/s10719-018-09854-y.
  • Sundin J, Nordlander S, Eutamene H, Alquier-Bacquie V, Cartier C, Theodorou V, Le Nevé B, Törnblom H, Simrén M, Öhman L. Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome. Neurogastroenterol Motil. 2019 Sep 13:e13701. doi:10.1111/nmo.13701.

2018

  • Mercier-Bonin M, Despax B, Raynaud P, Houdeau E, Thomas M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Crit Rev Food Sci Nutr. 2018 Apr 13;58(6):1023-1032. doi: 10.1080/10408398.2016.1243088.
  • Eutamene H, Beaufrand C, Harkat C, Theodorou V. The role of mucoprotectants in the management of gastrointestinal disorders. Expert Rev Gastroenterol Hepatol. 2018 Jan;12(1):83-90. doi: 10.1080/17474124.2018.1378573.
  • Theodorou V. Probiotics, stress and Irritable Bowel Syndrome (2018). Phytothérapie. 16:320-325.
  • Maresca M, Pinton P, Ajandouz EH, Menard S, Ferrier L, Oswald IP. Overview and Comparison of Intestinal Organotypic Models, Intestinal Cells, and Intestinal Explants Used for Toxicity Studies. Curr Top Microbiol Immunol. 2018 Sep 28. doi: 10.1007/82_2018_142.
  • Gillois K, Lévêque M, Théodorou V, Robert H, Mercier-Bonin M. Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives. Microorganisms. 2018 Jun 15;6(2). pii: E53. doi: 10.3390/microorganisms6020053.
  • Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Van Langendonck N, Gillet M, Cartier C, Baron M, Sommer C, Mallet V, Zill M, Robert H, Laurent F, Ellero-Simatos S, Théodorou V, Ménard S. Early life stress in mice  is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain Behav Immun. 2018 Oct;73:403-415. doi: 10.1016/j.bbi.2018.05.024.
  • Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. Eur J Nutr. 2018 Feb;57(1):155-166. doi: 10.1007/s00394-016-1304-z. 
  • Boulete IM, Thadi A, Beaufrand C, Patwa V, Joshi A, Foss JA, Eddy EP, Eutamene H, Palejwala VA, Theodorou V, Shailubhai K. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol. 2018 May 7;24(17):1888-1900. doi:10.3748/wjg.v24.i17.1888.
  • Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins TA. Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation. J Neurogastroenterol Motil. 2018 Jan 30;24(1):138-146. doi: 10.5056/jnm16167.
  • Talbot P, Radziwill-Bienkowska JM, Kamphuis JBJ, Steenkeste K, Bettini S, Robert V, Noordine ML, Mayeur C, Gaultier E, Langella P, Robbe-Masselot C, Houdeau E, Thomas M, Mercier-Bonin M. Food-grade TiO(2) is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection. J Nanobiotechnology. 2018 Jun 19;16(1):53. doi: 10.1186/s12951-018-0379-5.
  • Radziwill-Bienkowska JM, Talbot P, Kamphuis JBJ, Robert V, Cartier C, Fourquaux I, Lentzen E, Audinot JN, Jamme F, Réfrégiers M, Bardowski JK, Langella P, Kowalczyk M, Houdeau E, Thomas M, Mercier-Bonin M. Toxicity of Food-Grade TiO(2) to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging. Front Microbiol. 2018 Apr 24;9:794. doi: 10.3389/fmicb.2018.00794. eCollection 2018.
  • Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A,  Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L. Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose  Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor. Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877.
  • Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N. 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D. Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.
  • Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC,  Guillou H, Oswald IP, Loiseau N. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. Arch Toxicol. 2019 Feb;93(2):505-517.doi: 10.1007/s00204-018-2345-2.
  • Da Silva S, Keita ÅV, Mohlin S, Påhlman S, Theodorou V, Påhlman I, Mattson JP, Söderholm JD. A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative  Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models. Inflamm Bowel Dis. 2018 Mar 19;24(4):792-805. doi: 10.1093/ibd/izx079.
  • Ringot-Destrez B, D'Alessandro Z, Lacroix JM, Mercier-Bonin M, Léonard R, Robbe-Masselot C. A Sensitive and Rapid Method to Determin the Adhesion Capacity of Probiotics and Pathogenic Microorganisms to Human Gastrointestinal Mucins. Microorganisms. 2018 May 29;6(2). pii: E49. doi: 10.3390/microorganisms6020049.
  • Fernandez N, Wrzosek L, Radziwill-Bienkowska JM, Ringot-Destrez B, Duviau MP,  Noordine ML, Laroute V, Robert V, Cherbuy C, Daveran-Mingot ML, Cocaign-Bousquet  M, Léonard R, Robbe-Masselot C, Rul F, Ogier-Denis E, Thomas M, Mercier-Bonin M. Characterization of Mucus-Related Properties of Streptococcus thermophilus: From  Adhesion to Induction. Front Physiol. 2018 Jul 24;9:980. doi:10.3389/fphys.2018.00980.
  • Malaisé Y, Ménard S, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Guzylack-Piriou L. Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice. Arch Toxicol. 2018 Jan;92(1):347-358. doi: 10.1007/s00204-017-2038-2. Epub 2017 Jul 21.

2017

  • Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP,  Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO(2) impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep. 2017 Jan 20;7:40373. doi: 10.1038/srep40373.
  • Olier M, Sekkal S, Harkat C, Eutamene H, Theodorou V. Evaluation of reticulated gelatin-hibiscus-propolis against intestinal commensal species commonly associated with urinary tract infections. Future Microbiol. 2017 May;12:505-513. doi: 10.2217/fmb-2016-0175.
  • Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J, Méheust A, de Vos WM, Mercenier A, Nauta A, Garcia-Rodenas CL. Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G171-G193. doi:10.1152/ajpgi.00048.2015.
  • Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. Impact of mycotoxins on the intestine: are mucus and microbiota new targets? J Toxicol Environ Health B Crit Rev. 2017;20(5):249-275. doi:10.1080/10937404.2017.1326071.
  • Mercier-Bonin M, Chapot-Chartier MP. Surface Proteins of Lactococcus lactis: Bacterial Resources for Muco-adhesion in the Gastrointestinal Tract. Front Microbiol. 2017 Nov 23;8:2247. doi: 10.3389/fmicb.2017.02247.
  • Laroute V, Tormo H, Couderc C, Mercier-Bonin M, Le Bourgeois P, Cocaign-Bousquet M, Daveran-Mingot ML. From Genome to Phenotype: An Integrative Approach to Evaluate the Biodiversity of Lactococcus lactis. Microorganisms. 2017 May 19;5(2). pii: E27. doi: 10.3390/microorganisms5020027.
  • Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, Salvador-Cartier C, Laurent F, Théodorou V, Ménard S. Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity. Gastroenterology. 2017 Dec;153(6):1594-1606.e2.doi:10.1053/j.gastro.2017.08.044.
  • Kamphuis JBJ, Mercier-Bonin M, Eutamène H, Theodorou V. Mucus organisation is  shaped by colonic content; a new view. Sci Rep. 2017 Aug 17;7(1):8527. doi: 10.1038/s41598-017-08938-3.
  • Malaisé Y, Menard S, Cartier C, Gaultier E, Lasserre F, Lencina C, Harkat C, Geoffre N, Lakhal L, Castan I, Olier M, Houdeau E, Guzylack-Piriou L. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development. Sci Rep. 2017 Nov 3;7(1):14472. doi: 10.1038/s41598-017-15196-w.
  • Eutamène H, Garcia-Rodenas CL, Yvon S, d'Aldebert E, Foata F, Berger B, Sauser J, Theodorou V, Bergonzelli G, Mas E. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12994.
  • Radziwill-Bienkowska JM, Robert V, Drabot K, Chain F, Cherbuy C, Langella P,  Thomas M, Bardowski JK, Mercier-Bonin M, Kowalczyk M. Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain. Appl Microbiol Biotechnol. 2017 Jul;101(14):5709-5721. doi: 10.1007/s00253-017-8334-1. Epub 2017 May 24.
  • Vollnhals F, Audinot JN, Wirtz T, Mercier-Bonin M, Fourquaux I, Schroeppel B,  Kraushaar U, Lev-Ram V, Ellisman MH, Eswara S. Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity-Hue-Saturation and Laplacian Pyramid Methods for Image Fusion. Anal Chem. 2017 Oct 17;89(20):10702-10710. doi: 10.1021/acs.analchem.7b01256.
  • Zinni M, Zuena AR, Marconi V, Petrella C, Fusco I, Giuli C, Canu N, Severini C, Broccardo M, Theodorou V, Lattanzi R, Casolini P. Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system. PLoS One. 2017 Mar 7;12(3):e0173484. doi:10.1371/journal.pone.0173484.
  • Ducheix S, Montagner A, Polizzi A, Lasserre F, Régnier M, Marmugi A, Benhamed F, Bertrand-Michel J, Mselli-Lakhal L, Loiseau N, Martin PG, Lobaccaro JM, Ferrier L, Postic C, Guillou H. Dietary oleic acid regulates hepatic lipogenesis  through a liver X receptor-dependent signaling. PLoS One. 2017 Jul 21;12(7):e0181393. doi: 10.1371/journal.pone.0181393.

2016

  • Annaházi A, Ábrahám S, Farkas K, Rosztóczy A, Inczefi O, Földesi I, Szűcs M, Rutka M, Theodorou V, Eutamene H, Bueno L, Lázár G, Wittmann T, Molnár T, Róka R. A pilot study on faecal MMP-9: a new noninvasive diagnostic marker of colorectal cancer. Br J Cancer 2016;114(7):787-92.
  • Bessette C, Benoit B, Sekkal S, Bruno J, Estienne M, Leonil J, Ferrier L, Théodorou V, Plaisancié P. Protective effect of β-casofensin, a bioactive peptide from bovine β-casein, against indomethacin-induces intestinal lesions in rats. Mol Nutr Food Res 2016;60(4):823-33.
  • Castelain M, Duviau MP, Oxaran V, Schmitz P, Cocaign-Bousquet M, Loubière P, Piard JC, Mercier-Bonin M. Oligomerized backbone pilin helps piliated Lactococcus lactis to withstand shear flow. Biofouling. 2016;32(8):911-23.
  • Castelain M, Duviau MP, Canette A, Schmitz P, Loubière P, Cocaign-Bousquet M, Piard JC, Mercier-Bonin M. The Nanomechanical Properties of Lactococcus lactis Pili Are Conditioned by the Polymerized Backbone Pilin. PLoS One 2016;11(3):e0152053.
  • Eutamène H, Garcia-Rodenas CL, Yvon S, d'Aldebert E, Foata F, Berger B, Sauser J, Theodorou V, Bergonzelli G, Mas E. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil 2016 Dec 1. [Epub ahead of print]
  • Guellerin M, Passerini D, Fontagné-Faucher, Robert H, Gabriel V, Loux V, Klopp C, Le Loir Y, Coddeville M, Daveran-Mingot ML, Ritzenthaler P, Le Bourgeois P. Complete Genome Sequence of Lactococcus lactis subsp. lactis A12, a Strain Isolated from Wheat Sourdough. Genome Announc 2016; 4 (5) :e00692.
  • Miquel S, Martín R, Lashermes A, Gillet M, Meleine M, Gelot A, Eschalier A, Ardid D, Bermúdez-Humarán LG, Sokol H, Thomas M, Theodorou V, Langella P, Carvalho FA. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Sci Rep 2016;6:19399.
  • Radziwill-Bienkowska JM, Le DT, Szczesny P, Duviau MP, Aleksandrzak-Piekarczyk T, Loubière P, Mercier-Bonin M, Bardowski JK, Kowalczyk M. Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants. Appl Microbiol Biotechnol 2016;100(22):9605-9617.
  • Rincel M, Lépinay AL, Delage P, Fioramonti J, Théodorou V, Layé S, Darnaudéry M. Maternal high-fat diet prevents developmental programming by early-life stress. Transl Psychiatry 2016;6(11):e966.
  • Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, Allart S, Payré B, Capilla F, Cartier C, Peres C, Al Saati T, Theodorou V, Nelson DW, Yen CL, Collet X, Coméra C. Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond);2016;13:48. 
  • Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. Eur J Nutr 2016;Aug 31. [Epub ahead of print]
  • Wang C, Zanna S, Frateur I, Despax B, Raynaud P, Mercier-Bonin M, Marcus P. BSA adsorption on a plasma-deposited silver nanocomposite film controls silver release: a QCM and XPS-based modelling. Surf Coat Technol 2016;307:1-8.

2015

  • Da Silva S, Robbe-Masselot C, Raymond A, Mercade-Loubière M, Salvador-Cartier C, Ringot B, Léonard R, Fourquaux I, Ait-Belgnaoui A, Loubière P, Théodorou V, Mercier-Bonin M. Spatial localization and binding of the probiotic Lactobacillus farciminis to the rat intestinal mucosa: influence of chronic stress. PLoS One 2015;10(9):e0136048
  • Durand C, Pezet S, Eutamène H, Demarquay C, Mathieu N, Moussa L, Daudin R, Holler V, Sabourin JC, Milita F, François A, Théodorou V, Tamarat B, Benderitter M, Sémont A. Persistent visceral allodynia in rats exposed to colorectal irradiation is reverser by mesenchymal stromal cell treatment. Pain 2015;156(8):1465-76.
  • Martín R, Miquel S, Chain F, Natividad JM, Jury J, Lu J, Sokol H, Theodorou V, Bercik P, Verdu EF, Langella P, Bermúdez-Humarán LG. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol 2015;15:67.
  • Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 2015;83(6):2420-9. 

2014

  • Ménard S, Guzylack-Piriou L, Lévêque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Théodorou V, Houdeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J 2014;28(11):4893-900
  • Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Cartier C, Gillet M, Ferrier L, Loubière P, Dague E, Théodorou V, Mercier-Bonin M. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. Am J Physiol Gastrointest Liver Physiol 2014;307(4):G420-9
  • Ménard S, Guzylack-Piriou L, Lencina C, Leveque M, Naturel M, Sekkal S, Harkat C, Gaultier E, Olier M, Garcia-Villar R, Theodorou V, Houdeau E.Perinatal exposure to a low dose of bisphenol A impaired systemic cellular immune response and predisposes young rats to intestinal parasitic infection. PLoS One 2014;9(11):e112752.
  • Moussaoui N, Braniste V, Ait-Belgnaoui A, Gabanou M, Sekkal S, Olier M, Théodorou V, Martin PG, Houdeau E. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One, 9(2):e88382
  • Payros D, Sécher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Ceevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Théodorou V, Fioramonti J, Olier M, Oswald E. Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis. Gut Microbes 2014;5(3):313-25
  • Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamène H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Théodorou V. A multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol 2014;20(22):6832-43
  • Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot A, Cartier C, Houdeau E, Théodorou V, Tompkins T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil 2014;26:510-20
  • Le Dréan G, Haure-Mirande V, Ferrier L, Bonnet C, Hulin P, De Coppet P, Segain JP. Visceral adipose tissue and leptin increase colonic epithelial tight-junction permeability via a RhoA-ROCK dependent pathway. FASEB J 2014;28:1059-70
  • Olivier I, Théodorou V, Valet P, Castan-Laurell I, Ferrier L, Eutamène H. Modifications of mesenteric adipose tissue during moderate experimental colitis. Life Sci 2014;94:1-7
  • Stockinger S, Albers T, Duerr CU, Ménard S, Pütsep K, Andersson M, Hornef MW. Interleukin-13-mediated Paneth cell degranulation and antimicrobial peptide release. J Innate Immun 2014;6:530-41
  • Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrède JP, Olier M, Oswald E. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. J Infect Dis 2014;210(2):285-94

2013

  • Seyer A, Cantielo M, Bertrand-Michel J, Roques V, Nauze M, Bézirard V, Collet X, Touboul D, Brunelle A, Coméra C. Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion. PLoS One 2013;8(4):e58224
  • Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Saati TA, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. J Hepatol 2013 (in press).
  • Petrella C, Giuli C, Broccardo M, Eutamene H, Cartier C, Leveque M, Bedini A, Spampinato S, Bueno L, Theodorou V, Improta G, Agostini S. Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.  Pharmacol Res 2013;70(1):72-79.
  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, Braniste V, Ménard S, Theodorou V, Houdeau E. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012;7(11):e49547.
  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Houdeau E, Theodorou V.  A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats. Clin Nutr 2013;32(1):51-8.
  • Annaházi A, Molnár T, Farkas K, Rosztóczy A, Izbéki F, Gecse K, Inczefi O, Nagy F, Földesi I, Szűcs M, Dabek M, Ferrier L, Theodorou V, Bueno L, Wittmann T, Róka R. Fecal MMP-9: A new noninvasive differential diagnostic and activity marker in ulcerative colitis. Inflamm Bowel Dis 2013;19(2):316-20.

2012

  • Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M, Bacquié V, Pénary M, Gaultier E, Nougayrède JP, Fioramonti J, Oswald E. Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity.  Gut Microbes 2012;3(6):501-9. 
  • Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 2012;37(11):1885-95.
  • Agostini S, Goubern M, Tondereau V, Salvador-Cartier C, Bezirard V, Lévèque M, Keränen H, Theodorou V, Bourdu-Naturel S, Goupil-Feuillerat N, Legrain-Raspaud S, Eutamene H. A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats. Neurogastroenterol Motil 2012;24(4):376-e172
  • Serino M, Luche E, Gres S, Baylac A, Bergé M, Cenac C, Waget A, Klopp P, Iacovoni J, Klopp C, Mariette J, Bouchez O, Lluch J, Ouarné F, Monsan P, Valet P, Roques C, Amar J, Bouloumié A, Theodorou V, Burcelin R. Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut 2012;61(4):543-53
  • Annaházi A, Dabek M, Gecse K, Salvador-Cartier C, Polizzi A, Rosztóczy A, Róka R, Theodorou V, Wittmann T, Bueno L, Eutamene H. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain. Neurogastroenterol Motil 2012;24(1):76-85, e13
  • Vivinus-Nébot M, Dainese R, Anty R, Saint-Paul MC, Nano JL, Gonthier N, Marjoux S, Frin-Mathy G, Bernard G, Hébuterne X, Tran A, Theodorou V, Piche T. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 2012;107(1):75-81

 

Date de modification : 18 décembre 2024 | Date de création : 17 décembre 2024 | Rédaction : SY