Publications scientifiques de E9-PPCA

Valorisations de l'équipe de Prévention et Promotion de la Cancérogénèse par les Aliments

Articles de E9-PPCA dans des revues internationales à comité de lecture

Accès via la plateforme HAL INRAE


Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet-Santé Cohort and an in vivo Intervention Study in Rats

Mervant L, Tremblay-Franco M, Olier M, Jamin E, Martin JF, Trouilh L, Buisson C, Naud N, Maslo C, Héliès-Toussaint C, Fouché E, Kesse-Guyot E, Hercberg S, Galan P, Deschasaux-Tanguy M, Touvier M, Pierre F, Debrauwer L, Guéraud F.

Mol Nutr Food Res. 2023 Jan 16


Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study.

Srour B, Chazelas E, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Agaësse C, De Sa A, Lutchia R, Debras C, Sellem L, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Pierre F, Deschasaux-Tanguy M, Touvier M.

PLoS Med. 2023 Jan 17;20(1)


Nitrites, Nitrates, and Cardiovascular Outcomes: Are We Living "La Vie en Rose" With Pink Processed Meats?

Srour B, Chazelas E, Fezeu LK, Javaux G, Pierre F, Huybrechts I, Hercberg S, Deschasaux-Tanguy M, Kesse-Guyot E, Touvier M.

J Am Heart Assoc. 2022 Dec 20;11(24)

Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Santé cohort.

Bellicha A, Wendeu-Foyet G, Coumoul X, Koual M, Pierre F, Guéraud F, Zelek L, Debras C, Srour B, Sellem L, Kesse-Guyot E, Julia C, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M.

Am J Clin Nutr. 2022 Oct 6;116(4)

Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture.

Plaisancié P, Buisson C, Fouché E, Martin P, Noirot C, Maslo C, Dupuy J, Guéraud F, Pierre F.

PLoS One. 2022 Aug 30;17(8)


Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring.

Mazenc A, Mervant L, Maslo C, Lencina C, Bézirard V, Levêque M, Ahn I, Alquier-Bacquié V, Naud N, Héliès-Toussaint C, Debrauwer L, Chevolleau S, Guéraud F, Pierre FHF, Théodorou V, Olier M.

Redox Biol. 2022 Jul;53:102333

Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.

Guéguinou M, Ibrahim S, Bourgeais J, Robert A, Pathak T, Zhang X, Crottès D, Dupuy J, Ternant D, Monbet V, Guibon R, Flores-Romero H, Lefèvre A, Lerondel S, Le Pape A, Dumas JF, Frank PG, Girault A, Chautard R, Guéraud F, García-Sáez AJ, Ouaissi M, Emond P, Sire O, Hérault O, Fromont-Hankard G, Vandier C, Tougeron D, Trebak M, Raoul W, Lecomte T.

 Cell Mol Life Sci. 2022 May 8;79(6):284.

Nitrites and nitrates from food additives and natural sources and cancer risk: results from the NutriNet-Santé cohort.

 Chazelas E, Pierre F, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaesse C, De Sa A, Lutchia R, Gigandet S, Srour B, Debras C, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M.

Int J Epidemiol. 2022 Mar 18:

Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.

Guéguinou M, Ibrahim S, Bourgeais J, Robert A, Pathak T, Zhang X, Crottès D, Dupuy J, Ternant D, Monbet V, Guibon R, Flores-Romero H, Lefèvre A, Lerondel S, Le Pape A, Dumas JF, Frank PG, Girault A, Chautard R, Guéraud F, García-Sáez AJ, Ouaissi M, Emond P, Sire O, Hérault O, Fromont-Hankard G, Vandier C, Tougeron D, Trebak M, Raoul W, Lecomte T.

 Cell Mol Life Sci. 2022 May 8;79(6):284.

Nitrites and nitrates from food additives and natural sources and cancer risk: results from the NutriNet-Santé cohort.

 Chazelas E, Pierre F, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaesse C, De Sa A, Lutchia R, Gigandet S, Srour B, Debras C, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M.

Int J Epidemiol. 2022 Mar 18:


Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort.

 Chazelas E, Druesne-Pecollo N, Esseddik Y, de Edelenyi FS, Agaesse C, De Sa A, Lutchia R, Rebouillat P, Srour B, Debras C, Wendeu-Foyet G, Huybrechts I, Pierre F, Coumoul X, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M.

 Sci Rep. 2021 Oct 4;11(1):19680.

Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms.

 Arnaud LC, Gauthier T, Le Naour A, Hashim S, Naud N, Shay JW, Pierre FH, Boutet-Robinet E, Huc L.

 Cancers (Basel). 2021 Aug 27;13(17):4337

Towards Aldehydomics: Untargeted Trapping and Analysis of Reactive Diet-Related Carbonyl Compounds Formed in the Intestinal Lumen. 

 Chevolleau S, Noguer-Meireles MH, Mervant L, Martin JF, Jouanin I, Pierre F, Naud N, Guéraud F, Debrauwer L.

 Antioxidants (Basel). 2021 Aug 6;10(8):1261.

Anxiety is a potential effect modifier of the association between red and processed meat consumption and cancer risk: findings from the NutriNet-Santé cohort.

 Beslay M, Srour B, Deschasaux M, Fouché E, Naud N, Bacquié V, Guéraud F, Andreeva VA, Péneau S, Chazelas E, Debras C, Hercberg S, Latino-Martel P, Theodorou V, Pierre F, Touvier M.

 Eur J Nutr. 2021 Jun;60(4):1887-1896.

Regulation and Consumer Interest in an Antioxidant-Enriched Ham Associated with Reduced Colorectal Cancer Risks.

 Marette S, Guéraud F, Pierre F

 Nutrients. 2021 May 3;13(5):1542.

Public health risk-benefit assessment of red meat in France: Current consumption and alternative scenarios.

 Mota JO, Guillou S, Pierre F, Membré JM. 

 Food Chem Toxicol. 2021 Mar; 149:111994.

Osmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study.

 Mervant L, Tremblay-Franco M, Jamin EL, Kesse-Guyot E, Galan P, Martin JF, Guéraud F, Debrauwer L.

 Metabolomics. 2021 Jan 2;17(1):2.


Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation.

 Keller J, Chevolleau S, Noguer-Meireles MH, Pujos-Guillot E, Delosière M, Chantelauze C, Joly C, Blas-Y-Estrada F, Jouanin I, Durand D, Pierre F, Debrauwer L, Theodorou V, Guéraud F.

 Antioxidants (Basel). 2020 Dec 17;9(12):1293.

Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa.

 Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V.

 Gastroenterology. 2020 Feb;158(3):652-663.e6.

Opuntia cladode powders inhibit adipogenesis in 3 T3-F442A adipocytes and a high-fat-diet rat model by modifying metabolic parameters and favouring faecal fat excretion.

Héliès-Toussaint C, Fouché E, Naud N, Blas-Y-Estrada F, Del Socorro Santos- Diaz M, Nègre-Salvayre A, Barba de la Rosa AP, Guéraud F.

 BMC Complement Med Ther. 2020 Feb 5;20(1):33.

Global Profiling of Toxicologically Relevant Metabolites in Urine: Case Study of Reactive Aldehydes.

 Jamin EL, Costantino R, Mervant L, Martin JF, Jouanin I, Blas-Y-Estrada F, Guéraud F, Debrauwer L.

 Anal Chem. 2020 Jan 21;92(2):1746-1754.


Fecal microbiome as determinant of the effect of diet on colorectal cancer risk: comparison of meat-based versus pesco- vegetarian diets (the MeaTIc study). 

 Sofi F, Dinu M, Pagliai G, Pierre F, Gueraud F, Bowman J, Gerard P, Longo V, Giovannelli L, Caderni G, de Filippo C.

 Trials. 2019 Dec 9;20(1):688.

Estimation of the Burden of Iron Deficiency Anemia in France from Iron Intake: Methodological Approach

Juliana De Oliveira Mota , Patrick Tounian , Sandrine Guillou Fabrice Pierre , Jeanne-Marie Membré

Nutrients. 2019 Sep 1;11(9):2045.

Saturated, mono- and polyunsaturated fatty acid intake and cancer risk: results from the French prospective cohort NutriNet-Santé.

 Sellem L, Srour B, Guéraud F, Pierre F, Kesse-Guyot E, Fiolet T, Lavalette C, Egnell M, Latino-Martel P, Fassier P, Hercberg S, Galan P, Deschasaux M, Touvier M.

 Eur J Nutr.2019 Jun;58(4):1515-1527.

Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. 

 Martin OCB, Olier M, Ellero-Simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V, Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF.

 Microbiome. 2019 May 6;7(1):72.


Association between a pro plant-based dietary score and cancer risk in the prospective NutriNet-santé cohort.

 Kane-Diallo A, Srour B, Sellem L, Deschasaux M, Latino-Martel P, Hercberg S, Galan P, Fassier P, Guéraud F, Pierre FH, Kesse-Guyot E, Allès B, Touvier M.

 Int J Cancer. 2018 Nov 1;143(9):2168-2176.

Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption.

 Martin OCB, Naud N, Taché S, Debrauwer L, Chevolleau S, Dupuy J, Chantelauze C, Durand D, Pujos-Guillot E, Blas-Y-Estrada F,Urbano C, Kuhnle GGC, Santé-Lhoutellier V, Sayd T, Viala D, Blot A, Meunier N, Schlich P, Attaix D, Guéraud F, Scislowski V, Corpet DE, Pierre FHF.

Cancer Prev Res (Phila). 2018 Sep;11(9):569-580.

Helicobacter pylori-associated insulin resistance in asymptomatic sedentary young men does not correlate with inflammatory markers and urine levels of 8-iso-PGF2-α or 1,4- dihydroxynonane mercapturic acid. 

 Cherkas A, Golota S, Guéraud F, Abrahamovych O, Pichler C, Nersesyan A, Krupak V, Bugiichyk V, Yatskevych O, Pliatsko M, Eckl P, Knasmüller S. A

 Arch Physiol Biochem. 2018 Jul;124(3):275-285.

Development and validation of an ultra high performance liquid chromatography-lectrospray tandem mass spectrometry method using selective derivatisation, for the quantification of two reactive aldehydes produced by lipid peroxidation, HNE (4-hydroxy-2(E)-nonenal) and HHE (4-hydroxy-2(E)-hexenal) in faecal water.

 Chevolleau S, Noguer-Meireles MH, Jouanin I, Naud N, Pierre F, Gueraud F, Debrauwer L.

 J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15; 1083:171-179.

Red and processed meat intake and cancer risk: Results from the prospective NutriNet-Santé cohort study

Abou Diallo, Mélanie Deschasaux , Paule Latino-Martel, Serge Hercberg , Pilar Galan , Philippine Fassier , Benjamin Allès Françoise Guéraud, Fabrice H Pierre , Mathilde Touvier 

Int J Cancer. 2018 Jan 15 ; 142(2):230-237.


4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer.

Guéraud F.

 Free Radic Biol Med. 2017 Oct; 111:196-208.

Effects of dietary beef, pork, chicken and salmon on intestinal carcinogenesis in A/J Min/+ mice.

 Steppeler C, Sødring M, Egelandsdal B, Kirkhus B, Oostindjer M, Alvseike O, Gangsei LE, Hovland EM, Pierre F, Paulsen JE.

 PLoS One. 2017 Apr 20;12(4):e0176001.

Opuntia spp.: Characterization and Benefits in Chronic Diseases.

 Del Socorro Santos Díaz M, Barba de la Rosa AP, Héliès-Toussaint C, Guéraud F, Nègre-Salvayre A.

 Oxid Med Cell Longev. 2017; Apr 9; 2017:8634249.

Red Wine and Pomegranate Extracts Suppress Cured Meat Promotion of Colonic Mucin-Depleted Foci in Carcinogen-Induced Rats.

 Bastide NM, Naud N, Nassy G, Vendeuvre JL, Taché S, Guéraud F, Hobbs DA, Kuhnle GG, Corpet DE, Pierre FH.

 Nutr Cancer. 2017 Feb-Mar;69(2):289-298. 

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.

 Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E.

 Sci Rep. 2017 Jan 20; 7:40373.


Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation.

Diallo A, Deschasaux M, Partula V, Latino-Martel P, Srour B, Hercberg S, Galan P, Fassier P, Guéraud F, Pierre FH, Touvier M.

Oncotarget. 2016 Oct 12. PMID: 27738321. 

Short-term beef consumption promotes systemic oxidative stress, TMAO formation and inflammation in rats, and dietary fat content modulates these effects.

Van Hecke T, Jakobsen LM, Vossen E, Guéraud F, De Vos F, Pierre F, Bertram HC, De Smet S.

Food Funct. 2016 Sep 14;7(9):3760-71. PMID: 27531020

The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.

Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D.

Sci Rep. 2016 Aug 4;6:30776. PMID:27488617. IF: 5.525

Comparative shotgun proteomic analysis of wild and domesticated Opuntia spp. species shows a metabolic adaptation through domestication.

Pichereaux C, Hernández-Domínguez EE, Santos-Diaz Mdel S, Reyes-Agüero A, Astello-García M, Guéraud F, Negre-Salvayre A, Schiltz O, Rossignol M, Barba de la Rosa AP.

J Proteomics. 2016 Jun 30;143:353-64. PMID: 27072113. IF: 3.867

Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats.

Surya R, Héliès-Toussaint C, Martin OC, Gauthier T, Guéraud F, Taché S, Naud N, Jouanin I, Chantelauze C, Durand D, Joly C, Pujos-Guillot E, Pierre FH, Huc L.

Carcinogenesis. 2016 Jun;37(6):635-45. PMID:26992899. IF : 5.334

Helicobacter pylori in sedentary men is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stress.

Cherkas A, Eckl P, Gueraud F, Abrahamovych O, Serhiyenko V, Yatskevych O, Pliatsko M, Golota S.

Croat Med J. 2016 Apr 23;57(2):141-9. PMID: 27106356. IF: 1.57

Heme Iron Intake, Dietary Antioxidant Capacity, and Risk of Colorectal Adenomas in a Large Cohort Study of French Women

Bastide N, Morois S, Cadeau C, Kangas S, Serafini M, Gusto G, Dossus L, Pierre FH, Clavel-Chapelon F, Boutron-Ruault MC.

Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):640-7. PMID: 26823477. IF: 5.039

Dietary cladode powder from wild type and domesticated Opuntia species reduces atherogenesis in apoE knock-out mice.

Garoby-Salom S, Guéraud F, Camaré C, de la Rosa AP, Rossignol M, Santos Díaz Mdel S, Salvayre R, Negre-Salvayre A.

J Physiol Biochem. 2016 Mar;72(1):59-70. PMID: 26704378. IF: 2.054

Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: A review of the evidence.

Latino-Martel P, Cottet V, Druesne-Pecollo N, Pierre FH, Touillaud M, Touvier M, Vasson MP, Deschasaux M, Le Merdy J, Barrandon E, Ancellin R.

Crit Rev Oncol Hematol. 2016 Mar;99:308-23. Review. PMID: 26811140. IF : 3.622

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis.

Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J.

Front Cell Infect Microbiol. 2016 Mar 23;6:34. PMID:27047802. IF : 5.36


Antiatherogenic and antitumoral properties of Opuntia cladodes: inhibition of low density lipoprotein oxidation by vascular cells, and protection against the cytotoxicity of lipid oxidation product 4-hydroxynonenal in a colorectal cancer cellular model.

Keller J, Camaré C, Bernis C, Astello-García M, de la Rosa AP, Rossignol M, Del Socorro Santos Díaz M, Salvayre R, Negre-Salvayre A, Guéraud F.

J Physiol Biochem. 2015 Sep;71(3):577-87. PMID:25840808 IF : 1.97

Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats.

Guéraud F, Taché S, Steghens JP, Milkovic L, Borovic-Sunjic S, Zarkovic N, Gaultier E, Naud N, Héliès-Toussaint C, Pierre FH, Priymenko N.

Free Radic Biol Med. 2015 Jun;83:192-200 PMID: 25744414 IF: 5.73

A central role for heme iron in colon carcinogenesis associated with red meat intake.

Bastide NM, Chenni F, Audebert M, Santarelli RL, Taché S, Naud N, Baradat M, Jouanin I, Surya R, Hobbs DA, Kuhnle GG, Raymond-Letron I, Guéraud F, Corpet DE, Pierre FH.

Cancer Res. 2015 Mar 1;75(5):870-9. PMID: 25592152 IF: 9.33

"Twin peaks": searching for 4-hydroxynonenal urinary metabolites after oral administration in rats.

Keller J, Baradat M, Jouanin I, Debrauwer L, Guéraud F.

Redox Biol. 2015;4:136-48. PMID: 25560242

Antibiotic suppression of intestinal microbiota reduces heme-induced lipoperoxidation associated with colon carcinogenesis in rats.

Martin OC, Lin C, Naud N, Taché S, Raymond-Letron I, Corpet DE, Pierre FH.

Nutr Cancer. 2015;67(1):119-25. PMID: 25514759 (5-Y IF : 2.947, Oncology 119/202, Q3)

Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D.

Toxicol In Vitro. 2015 Oct;29(7):1597-608. PMID: 26086121 IF: 2.90

Stefan Grimm, 1963-2014, a tragic loss for the scientific community.

Mahul-Mellier AL, Huc L, Lemarié A, Irshad S, Hwang M, Datler C, Pazarentzos E.

Cell Death Differ. 2015 Feb;22(2):247. PMID: 25578148 IF: 8.18


Epidemiological evidence for the association between red and processed meat intake and colorectal cancer.

Corpet DE, De Smet S, Demeyer D.

Meat Sci. 2014 Oct;98(2):115. No abstract available. PMID:24927046 (5-Y IF: 2.901, Food Science & Technology 34/123, Q2)

The role of red and processed meat in colorectal cancer development: a perspective.

Oostindjer M, Alexander J, Amdam GV, Andersen G, Bryan NS, Chen D, Corpet DE, De Smet S, Dragsted LO, Haug A, Karlsson AH, Kleter G, de Kok TM, Kulseng B, Milkowski AL, Martin RJ, Pajari AM, Paulsen JE, Pickova J, Rudi K, Sødring M, Weed DL, Egelandsdal B.

Meat Sci. 2014 Aug;97(4):583-96. PMID:24769880 (5-Y IF: 2.901, Food Science & Technology 34/123, Q2)

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.

Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L.

Toxicology. 2014 Nov 5;325:133-43. PMID: 25168180 (5-Y IF: 3.884, Toxicology 14/87, Q1)

Ergovaline in tall fescue and its effect on health, milk quality, biochemical parameters, oxidative status, and drug metabolizing enzymes of lactating ewes.

Zbib N, Repussard C, Tardieu D, Priymenko N, Domange C, Guerre P.

J Anim Sci. 2014 Nov;92(11):5112-23. PMID:25253811

Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study.

Héliès-Toussaint C, Peyre L, Costanzo C, Chagnon MC, Rahmani R.

Toxicol Appl Pharmacol. 2014 Oct 15;280(2):224-35. PMID: 25111128

Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease.

Peyre L, Rouimi P, de Sousa G, Héliès-Toussaint C, Carré B, Barcellini S, Chagnon MC, Rahmani R.

Food Chem Toxicol. 2014 Aug;70:9-18. PMID: 24793377 (5-Y IF : 4.163 , Toxicology, 16/87, Q1)

Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling.

Chevillard-Briet M, Quaranta M, Grézy A, Mattera L, Courilleau C, Philippe M, Mercier P, Corpet D, Lough J, Ueda T, Fukunaga R, Trouche D, Escaffit F.

Hum Mol Genet. 2014 Apr 15;23(8):2120-31. PMID:24287617 (5-Y IF: 6.968, Genetics & Heredity 16/164 Q1)


Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance.

Dalleau S, Baradat M, Guéraud F, Huc L.

Cell Death Differ. 2013 Dec;20(12):1615-30. Review. PMID: 24096871

Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon.

Santarelli RL, Naud N, Taché S, Guéraud F, Vendeuvre JL, Zhou L, Anwar MM, Mirvish SS, Corpet DE,Pierre FH.

Int J Cancer. 2013 Dec 1;133(11):2533-41. PMID: 23712585. (5-Y IF: 5.497, Oncology 34/202, Q1)

Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.

Pierre FH, Martin OC, Santarelli RL, Taché S, Naud N, Guéraud F, Audebert M, Dupuy J, Meunier N, Attaix D, Vendeuvre JL, Mirvish SS, Kuhnle GC, Cano N, Corpet DE.

Am J Clin Nutr. 2013 Nov;98(5):1255-62 PMID: 24025632 (5-Y IF: 7.802, Nutrition & Dietetics 3/78, Q1)

Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite.

Chenni FZ, Taché S, Naud N, Guéraud F, Hobbs DA, Kunhle GG, Pierre FH, Corpet DE.

Nutr Cancer. 2013;65(2):227-33. PMID: 23441609 (5-Y IF : 2.947, Oncology 119/202, Q3)

Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse.

Domange C, Schroeder H, Violle N, Peiffer J, Canlet C, Paris A, Priymenko N.

Neurotoxicology. 2013 Sep;38:74-83. PMID:23811200. (5-Y IF : 3.291, Toxicology 26/87, Q2)

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.

Garciarena CD, Ma YL, Swietach P, Huc L, Vaughan-Jones RD.

J Physiol. 2013 May 1;591(Pt 9):2287-306. PMID: 23420656 (5-Y IF: 5.021, Physiology 8/81, Q1)

Protein disulfide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins.

Muller C, Bandemer J, Vindis C, Camaré C, Mucher E, Guéraud F, Larroque-Cardoso P, Bernis C, Auge N, Salvayre R, Negre-Salvayre A.

Antioxid Redox Signal. 2013 Mar 1;18(7):731-42. PMID: 23083489. (5-Y IF: 8.499, Endocrinology & Metabolism 9/123, Q1)


Induction of colonic aberrant crypts in mice by feeding apparent N-nitroso compounds derived from hot dogs.

Davis ME, Lisowyj MP, Zhou L, Wisecarver JL, Gulizia JM, Shostrom VK, Naud N,Corpet DE, Mirvish SS.

Nutr Cancer. 2012;64(2):342-9. PMID:22293095. (5-Y IF : 2.947, Oncology 119/202, Q3)

Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.

Kowalski-Chauvel A, Najib S, Tikhonova IG, Huc L, Lopez F, Martinez LO, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

J Biol Chem. 2012 Nov 30;287(49):41458-68. PMID: 23055519. (5-Y IF : 4.863, Biochemistry & Molecular Biology 65/291, Q1)

Mécanismes de l'effet pro-cancer des viandes : revue bibliographique.

Corpet DE,

Revue Méd. Vét. 2012, 163, 1, 43-48


Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells.

Huc L, Lemarié A, Guéraud F, Héliès-Toussaint C.

Toxicol In Vitro. 2012 Aug;26(5):709-17. PMID:22515966  IF: 2.546

Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.

Marmugi A, Ducheix S, Lasserre F, Polizzi A, Paris A, Priymenko N, Bertrand-Michel J, Pineau T, Guillou H, Martin PG, Mselli-Lakhal L.

Hepatology. 2012 Feb;55(2):395-407. PMID:21932408. (5-Y IF : 11.532, Gastroenterology & hepatology 3/74, Q1)

Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.

Dendelé B, Tekpli X, Sergent O, Dimanche-Boitrel MT, Holme JA, Huc L, Lagadic-Gossmann D.

Toxicol In Vitro. 2012 Feb;26(1):94-101. PMID:22100782 (5-Y IF : 3.151, Toxicology 23/87, Q2)

NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function.

Tekpli X, Huc L, Sergent O, Dendelé B, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D.

Cell Physiol Biochem. 2012;29(5-6):657-66. PMID: 22613966

Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins.

Vásquez-Garzón VR, Rouimi P, Jouanin I, Waeg G, Zarkovic N, Villa-Treviño S, Guéraud F.

Toxicol Mech Methods. 2012 May;22(4):296-304. PMID: 22475225

Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate.

Bartley AA, Morrison, Dupuy J, Bartley Y, Sutra JF, Menez C, Alvinerie M, Jackson F, Devin L, A. Lespine

Vet Parasitol, 187: 464-472. (5-Y IF : 2.719, Veterinary Sciences 5/129, Q1)


Red meat and colon cancer: should we become vegetarians, or can we make meat safer?

Corpet DE.

Meat Sci. 2011 Nov;89(3):310-6. Review.PMID:21558046  IF=2.62

4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.

Baradat M, Jouanin I, Dalleau S, Taché S, Gieules M, Debrauwer L, Canlet C, Huc L, Dupuy J, Pierre FH, Guéraud F.

Chem Res Toxicol. 2011 Nov 21;24(11):1984-93. PMID: 21967605 IF=4.15

Liquid chromatography/electrospray ionisation mass spectrometric tracking of 4-hydroxy-2(E)-nonenal biotransformations by mouse colon epithelial cells using [1,2-13C2]-4-hydroxy-2(E)-nonenal as stable isotope tracer.

Jouanin I, Baradat M, Gieules M, Taché S, Pierre FH, Guéraud F, Debrauwer L.

Rapid Commun Mass Spectrom. 2011 Oct 15;25(19):2675-81. PMID: 21913243 IF=2.85

Oxidative stress in dog with heart failure: the role of dietary Fatty acids and antioxidants.

Sagols E, Priymenko N.

Vet Med Int. 2011 Apr 6;2011:180206. PMID:21547262

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction.

Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S.

Cell Death Differ. 2011 Feb;18(2):338-49. PMID:20706275 IF=9.05

Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved.

Bastide NM, Pierre FH, Corpet DE.

Cancer Prev Res (Phila). 2011 Feb;4(2):177-84. PMID: 21209396 IF=6.00

Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis.

Allam O, Bahuaud D, Taché S, Naud N, Corpet DE, Pierre FH.

Br J Nutr. 2011 Feb;105(3):384-92. PMID: 21134327  IF=3.45

Involvement of G-463A MPO gene polymorphism in the response of postmenopausal women to hormone therapy.

del Agua AR, Aurrekoetxea I, Elorriaga MA, Rodriguez F, Guéraud F, Ruiz-Larrea MB, Ruiz-Sanz JI.

Menopause. 2011 May;18(5):575-81. PMID:21242819  IF=3.32


Longitudinal study of Australian stringhalt cases in France.

Domange C, Casteignau A, Collignon G, Pumarola M, Priymenko N.

J Anim Physiol Anim Nutr (Berl). 2010 Dec;94(6):712-20. PMID:20662969

Chemistry and biochemistry of lipid peroxidation products.

Guéraud F, Atalay M, Bresgen N, Cipak A, Eckl PM, Huc L, Jouanin I, Siems W, Uchida K.

Free Radic Res. 2010 Oct;44(10):1098-124. Review.PMID:20836659

Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats.

Santarelli RL, Vendeuvre JL, Naud N, Taché S, Guéraud F, Viau M, Genot C, Corpet DE,Pierre FH.

Cancer Prev Res (Phila). 2010 Jul;3(7):852-64. PMID: 20530708 IF=6.00

Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.

Jourdan F, Cottret L, Huc L, Wildridge D, Scheltema R, Hillenweck A, Barrett MP, Zalko D, Watson DG, Debrauwer L.

Metabolomics. 2010 Jun;6(2):312-321. PMID: 20526351

Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon.

Pierre FH, Santarelli RL, Allam O, Tache S, Naud N, Gueraud F, Corpet DE.

Nutr Cancer. 2010;62(5):567-73. PMID: 20574917. IF=2.63

Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.

Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D.

Toxicol Appl Pharmacol. 2010 Feb 15;243(1):68-76. PMID: 19931295

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats.

Marquez-Quiñones A, Cipak A, Zarkovic K, Fattel-Fazenda S, Villa-Treviño S, Waeg G, Zarkovic N, Guéraud F.

Free Radic Res. 2010 Feb;44(2):119-27. PMID: 19886749  IF=2.826

Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.

Potier M, Tran TA, Chantome A, Girault A, Joulin V, Bougnoux P, Vandier C, Pierre F.

Biochem Biophys Res Commun. 2010 Jun 18;397(1):42-7. PMID: 20519134

Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing Apc Min mutation.

Bellocq D, Molina J, Rathahao-Paris E, Taché S,Pierre F, Paris A.

Steroids. 2010 Oct;75(10):665-75. PMID: 20417221


Orthologous metabonomic qualification of a rodent model combined with magnetic resonance imaging for an integrated evaluation of the toxicity of Hypochoeris radicata.

Domange C, Canlet C, Traore A, Biélicki G, Keller C, Paris A, Priymenko N.

Chem Res Toxicol. 2008 Nov;21(11):2082-96. PMID:18783252. IF : 3,491

Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat.

Corpet DE, Taché S, Archer MC, Bruce WR.

Food Chem Toxicol. 2008 Sep;46(9):3037-42. PMID:18585427 . IF : 2,321

Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence.

Santarelli RL, Pierre F, Corpet DE.

Nutr Cancer. 2008;60(2):131-44. Review.PMID:18444144. IF : 2,627

Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.

Pierre F, Santarelli R, Taché S, Guéraud F, Corpet DE.

Br J Nutr. 2008 May;99(5):1000-6. PMID:17953789. IF : 2,764

Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.

Lacroix J, Poët M, Huc L, Morello V, Djerbi N, Ragno M, Rissel M, Tekpli X, Gounon P, Lagadic-Gossmann D, Counillon L.

Biochemistry. 2008 Dec 23;47(51):13674-85 PMID: 19035652, IF : 3,379

Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains.

Tekpli X, Huc L, Lacroix J, Rissel M, Poët M, Noël J, Dimanche-Boitrel MT, Counillon L, Lagadic-Gossmann D.

J Cell Physiol. 2008 Jul;216(1):207-20. PMID: 18264982. IF : 4,313

A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.

Gorria M, Tekpli X, Rissel M, Sergent O, Huc L, Landvik N, Fardel O, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D.

Toxicol Appl Pharmacol. 2008 Apr 15;228(2):212-24. PMID: 18255115, IF : 3,364

Oxidative stress and cystic fibrosis-related diabetes: a pilot study in children.

Ntimbane T, Krishnamoorthy P, Huot C, Legault L, Jacob SV, Brunet S, Levy E, Guéraud F, Lands LC, Comte B.

J Cyst Fibros. 2008 Sep;7(5):373-84. PMID: 18420468 IF : 1,550

High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.

Bellocq D, Molina J, Rathahao E, Canlet C, Taché S, Martin PG, Pierre F, Paris A.

Mutat Res. 2008 May 31;653(1-2):34-43. PMID: 18434241, IF : 2,363


Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion.

Taché S, Ladam A, Corpet DE.

Eur J Cancer. 2007 Jan;43(2):454-8. PMID:17188859. IF : 4,454

c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis.

Huc L, Tekpli X, Holme JA, Rissel M, Solhaug A, Gardyn C, Le Moigne G, Gorria M, Dimanche-Boitrel MT, Lagadic-Gossmann D.

Cancer Res. 2007 Feb 15;67(4):1696-705. PMID: 17308111. IF=7.514

Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.

Holme JA, Gorria M, Arlt VM, Ovrebø S, Solhaug A, Tekpli X, Landvik NE, Huc L, Fardel O, Lagadic-Gossmann D.

Chem Biol Interact. 2007 Apr 5;167(1):41-55. PMID: 17289009. IF=3.077

TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.

Meurette O, Rebillard A, Huc L, Le Moigne G, Merino D, Micheau O, Lagadic-Gossmann D, Dimanche-Boitrel MT.

Cancer Res. 2007 Jan 1;67(1):218-26. PMID: 17210702 . IF=7.514

Proteasome activity deregulation in LEC rat hepatitis: following the insights of transcriptomic analysis.

Marquez-Quiñones A, Paris A, Roussel B, Perez-Carreon J, Le Berre V, François JM, Villa-Treviño S, Guéraud F.

OMICS. 2007 Winter;11(4):367-84. PMID: 18092909. IF : 3.013

Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats.

Pierre F, Tache S, Guéraud F, Rerole AL, Jourdan ML, Petit C.

Carcinogenesis. 2007 Feb;28(2):321-7. PMID: 16885197. IF : 5.406


New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.

Pierre F, Peiro G, Taché S, Cross AJ, Bingham SA, Gasc N, Gottardi G, Corpet DE,Guéraud F.

Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2274-9. PMID:17119057. IF : 4,289

Polyethylene glycol and prevalence of colorectal adenomas.

Dorval E, Jankowski JM, Barbieux JP, Viguier J, Bertrand P, Brondin B, Bougnoux P, Corpet DE.

Gastroenterol Clin Biol. 2006 Oct;30(10):1196-9. PMID:17075478. IF : 0.75

Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol.

Gorria M, Tekpli X, Sergent O, Huc L, Gaboriau F, Rissel M, Chevanne M, Dimanche-Boitrel MT, Lagadic-Gossmann D.

Ann N Y Acad Sci. 2006 Dec;1090:108-12. PMID: 17384252. IF=2.303

Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport.

Gorria M, Huc L, Sergent O, Rebillard A, Gaboriau F, Dimanche-Boitrel MT, Lagadic-Gossmann D.

Biochem Pharmacol. 2006 Nov 15;72(10):1343-53. PMID: 16962073. IF=4.838

Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells.

Huc L, Rissel M, Solhaug A, Tekpli X, Gorria M, Torriglia A, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D.

J Cell Physiol. 2006 Sep;208(3):527-37. PMID: 16688778. IF=4.313

New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.

Pierre F, Peiro G, Taché S, Cross AJ, Bingham SA, Gasc N, Gottardi G, Corpet DE, Guéraud F.

Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2274-9. PMID: 17119057. IF : 4,289


Hypocalcaemia due to nutritional calcium deficiency and hypoparathyroidism in an adult dog.

Diquélou A, Chaput C, Benoit E, Priymenko N.

Vet Rec. 2005 Jan 8;156(2):45-8. PMID:15675523

TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.

Meurette O, Huc L, Rebillard A, Le Moigne G, Lagadic-Gossmann D, Dimanche-Boitrel MT.

Ann N Y Acad Sci. 2005 Nov;1056:379-87. PMID: 16387703. IF=2.303

Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes.

Sergent O, Pereira M, Belhomme C, Chevanne M, Huc L, Lagadic-Gossmann D.

J Pharmacol Exp Ther. 2005 Apr;313(1):104-11. PMID: 15634942. IF=4.31

 How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men

Corpet DE, Pierre F.

Eur. J. Cancer (2005) 41, 1911-1922. IF : 3.706

Hypocalcaemia due to nutritional calcium deficiency and hypoparathyroidism in an adult dog.

Diquélou A, Chaput C, Benoit E, Priymenko N.

Vet Rec. 2005 Jan 8;156(2):45-8. IF : 1,017

Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/ Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15Ra complex and CD4 +CD25 + T cells are the main targets

Forest V, Pierre F, Bassonga E, Meflah K and Menanteau J

Cancer Immunol. Immunother. 54 (2005) 78-86. IF : 4.086

 Enantioselective metabolism of (R)- and (S)-4-hydroxynonenal in rat.

Guéraud F, Crouzet F, Alary J, Rao D, Debrauwer L, Laurent F and Cravedi JP

BioFactors 24, 97-104. IF : 1,162

1,4-Dihydroxynonene mercapturic acid, an urinary metabolite of 4-hydroxynonenal, as a biomarker of lipid peroxidation.

Peiro GA, Alary JA, Cravedi JP, Rathahao EA, Steghens JPA and Guéraud FA

BioFactors 24, 89-96. IF : 1,162

Impact of residual and therapeutic doses of ciprofloxacin in the human-flora-associated mice model,

Perrin-Guyomard A, Poul JM, Corpet DE, Sanders P, Fernandez AH and Bartholomew M

Regul. Toxicol. Pharmacol.  42, 151-160. IF=1.44

Liquid chromatography - multistage tandem mass spectrometry for the quantification of dihydroxynonene mercapturic acid (DHN-MA), a urinary end-metabolite of 4-hydroxynonenal

Rathahao E, Peiro G, Alary J, Guéraud F and Debrauwer L.

Anal. Bioanal. Chem. (2005) 381, 1532-1539. IF : 2.695


Fabrice Pierre et Françoise Guéraud


180, chemin de Tournefeuille - BP.93173
F-31027 TOULOUSE cedex 3, France

Date de modification : 08 juin 2023 | Date de création : 16 juillet 2010 | Rédaction : CHT